This is really really cool biology published in +Nature News & Comment ! XIST is one of most famous (in my opinion) ncRNAs out there and is normally used in X-chromosome inactivation in females (so you get one active and one inactive chromosome)
In this study they took the XIST gene and put it inside chromosome 21 and in more detail into down syndrom iPS cell lines (so chr21 is a trisomy). And then the cool stuff happened…. by doing this the XIST transcript transformed the 3rd chromosome copy into a barr body (inactive chromosome) leaving 2 active normal chromosomes behind. By doing so the down syndrome genetic effect got genetically 'fixed', awesome!
Anyway, read the whole paper here http://bit.ly/12JJ3MU
#science #nature #xchromosome #inactivation #XIST #downsyndrome
Population study in Italy suggests that though old age increase rate of #Alzheimer and #Cancer it is very rare that a given person has both cancer as well alzheimer.
I can somehow understand how cancer kills before alzheimer sets in but it's striking that old people with alzheimer seem to be "cancer free".
Anyone any biological take on this?
#science #paper #populationstudy
Inverse occurrence of cancer and Alzheimer disease
Abstract Objective: To evaluate the incidence of cancer in persons with Alzheimer disease (AD) and the incidence of AD dementia in persons with cancer. Methods: This was a cohort study in Northern Italy on more than 1 million residents. Cancer incidence was derived from the local health authority (ASL-Mi1) tumor registry and AD dementia incidence from registries of drug prescriptions, hospitalizations, and payment exemptions. Expected cases o…
Population study in Italy suggests that though old age increase rate of #Alzheimer…
Population study in Italy suggests that though old age increase rate of #Alzheimer and #Cancer it is very rare that a given person has both cancer as well alzheimer.
I can somehow understand how cancer kills before alzheimer sets in but it's striking that old people with alzheimer seem to be "cancer free".
Anyone any biological take on this?
Embedded Link
Inverse occurrence of cancer and Alzheimer disease
Abstract Objective: To evaluate the incidence of cancer in persons with Alzheimer disease (AD) and the incidence of AD dementia in persons with cancer. Methods: This was a cohort study in Northern Italy on more than 1 million residents. Cancer incidence was derived from the local health authority (ASL-Mi1) tumor registry and AD dementia incidence from registries of drug prescriptions, hospitalizations, and payment exemptions. Expected cases o…
Want to understand what this ENCODE thing is all about? Watch this amazing animated…
Want to understand what this ENCODE thing is all about? Watch this amazing animated movie very elegantly explaining the basics of what makes this project so exciting and what the implications are on a level that even non scientist understand! Brilliantly done +Nature Publishing Group!
Genomes Certainly Are Tricky!
Thanks +Benedetta Frida Baldi for this great find!
The Story of You: ENCODE and the human genome
Ever since a monk called Mendel started breeding pea plants we’ve been learning about our genomes. In 1953, Watson, Crick and Franklin described the structur…
Ant-enna: a project where the National Trust is gluing antenna's to all 1000…
Ant-enna: a project where the National Trust is gluing antenna's to all 1000 ants to study their movements and interactions in a local forest. Sounds like a super cool study going on there (not the least because it features ants, ants are awesome!). Can't wait to see results from this.